Last edited by Akir
Thursday, July 23, 2020 | History

6 edition of Alterations Of Excitation-contraction Coupling In The Failing Human Heart found in the catalog.

Alterations Of Excitation-contraction Coupling In The Failing Human Heart

by G Hassenfuss

  • 400 Want to read
  • 8 Currently reading

Published by STEINKOPFF: DARMSTADT .
Written in English

    Subjects:
  • Cardiology,
  • Life Sciences - Anatomy & Physiology,
  • Cardiovascular System Physiology,
  • Medical,
  • Medical / Nursing

  • The Physical Object
    FormatHardcover
    Number of Pages197
    ID Numbers
    Open LibraryOL12921675M
    ISBN 103798510474
    ISBN 109783798510470

    to explore for the restoration of the altered excitation-contraction coupling. In this study, we performed an in-silico sensitivity analysis to understand the mechanisms modulating calcium dynamics in failing human hearts. Using a modified version of the O’Hara et al. human ventricular action potential model, we simulated differentAuthor: Maria Teresa Mora, Jose M Ferrero, Beatriz Trenor.   Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. The alterations are similar to those reported in human heart failure, which reinforces the utility of the pacing-induced dog model as a surrogate for the human Cited by:

    Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca 2+ handling have not been investigated in this model. We now show that left ventricular midmyocardial myocytes isolated from dogs subjected to 3 to 4 weeks of rapid pacing have prolonged action potentials and Ca Cited by: Excitation-contraction coupling alterations in mdx and utrophin/dystrophin double knockout mice: a comparative study. Am J Physiol Cell Physiol C–C, Link ISI Google Scholar; Chan S, Head SI. The role of branched fibres in the pathogenesis of Duchenne muscular dystrophy. Exp Physiol –, Crossref PubMed Cited by: 9.

    Xanthine oxidase (XO) activity contributes to both abnormal excitation-contraction (EC) coupling and cardiac remodeling in heart failure (HF). β-Adrenergic hyporesponsiveness and abnormalities in Ca 2+ cycling proteins are mechanistically linked features of the HF phenotype. Accordingly, we hypothesized that XO influences β-adrenergic responsiveness and expression of genes whose products Cited by: Central dogma of EC coupling. For the purposes of brief review, Fig. 1A depicts the cellular events that underlie a single heart beat and illustrate phenomena related to global transsarcolemmal Ca 2+ fluxes within a single ventricular myocyte. The central dogma underlying cardiac EC coupling includes the theory of Ca 2+-induced Ca 2+ release, whereby small increases in Ca 2+ in the vicinity of Cited by:


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Alterations Of Excitation-contraction Coupling In The Failing Human Heart by G Hassenfuss Download PDF EPUB FB2

Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium.

"This book provides an approach to summarize the current knowledge on the alteration of excitation-contraction coupling processes in the failing human heart.

On the basis of the most recent data, international experts in this field elaborate on the functional, biochemical, and molecular aspects of excitation-contraction coupling processes in the mammalian myocardium. Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human : Steinkopff.

The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists.

Atar, W. Gao and E. tions of Excitation—Contraction Coupling in Stunned Myocardium and in Failing Myocardium. Journal of Molecular and Cellular Cardiology () 27, –Although both myocardial stunning and chronic heart failure are characterized by contractile dysfunction, there are profound differences in their underlying by: Key Words: excitation-contraction couplingn action potential n sarcoplasmic reticulum n Ca21 uptake n heart failure Recent evidence indicates that the hemodynamic alterations accompanying heart failure are coincident with a common pattern of electrophysiological and excitation-contraction (E-C) coupling changes at the cellular level.

The effect of the loss of the notch in the human action potential (AP) during heart failure was examined by voltage clamping rat ventricular myocytes with human APs and recording intracellular Ca 2+ with fluorescent dyes. Loss of the notch resulted in about a 50% reduction in the initial phase of the Ca 2+ transient due to reduced ability of the l-type Ca 2+ channel to trigger by: The calcium uptake (in the presence of 5 mM oxalate) by the heavy microsomes of the failing heart was similar to that of the control heart.

On the other hand, both the rate and extent of energy-linked calcium binding (in the absence of Pi and succinate) and calcium uptake (in the presence of 4 mM Pi and 5 mM succinate) by mitochondria were greatly reduced in the failing heart in comparison to the by:   Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important.

It is crucial to the very process that enables the chambers of the heart to contract Cited by: Cardiac excitation-contraction coupling (Cardiac EC coupling) describes the series of events, from the production of an electrical impulse (action potential) to the contraction of muscles in the heart.

This process is of vital importance as it allows for the heart to beat in a controlled manner, without the need for conscious input. EC coupling results in the sequential contraction of the. Excitation-contraction coupling (ECC) is the process whereby an action potential triggers a myocyte to contract.

When a myocyte is depolarized. Alterations of Excitation Contraction Coupling in the Failing Human Heart Book Summary: Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium.

In. Cardiac excitation–contraction coupling is the process from electrical excitation of the myocyte to contraction of the heart (which propels blood out). The regulation of cytosolic Ca2+ concentration during excitation-contraction coupling is altered in the failing human heart.

Previous studies have focused on disturbances in Ca2+ release and reuptake from the sarcoplasmic reticulum (SR), whereas functional studies of the cardiac Na(+)-Ca2+ exchanger, another important determinant of myocyte homeostasis, are lacking for the failing human heart.

Recent studies performed in isolated human myocardium suggested that altered excitation-contraction coupling and, in particular, altered sarcoplasmic reticulum (SR) calcium handling may be of significant pathophysiological relevance in human heart failure.

1 2 3 4 5 SR function may be disturbed at the level of calcium uptake by SR Ca 2+-ATPase or its regulatory protein phospholamban at the Cited by: Mechanistically, the hallmarks of the failing heart include abnormal energy metabolism, increased production of reactive oxygen species (ROS) and defects in excitation-contraction coupling.

Start studying Excitation-Contraction Coupling. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Name the human mm disease related to a mutation in this receptor: RyR2 (heart) (given to LONG TERM maintenance treatment of heart failure--acts as a protection against the catecholamines that overstimulate the.

In order to overcome this difficulty, experiments must be performed on failing and non-failing human heart tissue using methods that provide a window to examine the contractile and excitation–contraction coupling behavior of these tissues more directly. This requires the use of thin strips of human heart muscle for thermo–mechanical by: Cardiac excitation-contraction coupling.

Nature | Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most : Donald Bers.

Excitation-Contraction Coupling and Cardiac Contractile Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields/5(4).

Alterations of Excitation-Contraction coupling in the Failing Human Heart by. (1st Edition)by Gerd [Editor] Hasenfuss, Hanjörg [Editor] Just, G.

Hassenfuss Hardcover, Pages, Published ISBN / ISBN / Need it Fast? 2 day shipping options This book provides an approach to summarize the current knowledge on the Book Edition: 1st Edition.Calcium handling proteins in the failing human heart.- Role of c AMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure.- Contributions of Ca2+-influx via the L-type Ca2+-current and Ca2+-release from the sarcoplasmic reticulum to [Ca2+]i-transients in human myocytesexcitation-contraction coupling in skeletal muscle [92].

However, excitation-contraction uncoupling has only recently been proposed as a contributing factor to the process of sarcopenia [,]. The molecular basis for excitation-contraction uncoupling in muscles from aging mammals is a .